A model independent parametrization of the optical properties of the refrozen IceCube drill holes

The IceCube Neutrino Observatory deployed 5160 digital optical modules (DOMs) in a cubic kilometer of deep, glacial ice below the geographic South Pole, recording the Cherenkov light of passing charged particles. While the optical properties of the undisturbed ice are nowadays well understood, the properties of the refrozen drill holes still pose a challenge. From camera observations, we expect a central, strongly scattering column shadowing a part of the DOMs' sensitive area. In MC simulation, this effect is commonly modeled as a modification to the DOMs' angular acceptance curve, reducing the forward sensitivity of the DOMs. The associated uncertainty is a dominant detector systematic for neutrino oscillation studies as well as high-energy cascade reconstructions. Over the years, several measurements and fits of the drill holes' optical properties and of the angular acceptance curve have been proposed, some of which are in tension. Here, we present a principle component analysis, which allows us to interpolate between all suggested scenarios, and thus provide a complete systematic variation within a unified framework at analysis level.Comment: Presented at the 38th International Cosmic Ray Conference (ICRC2023). See arXiv:2307.13047 for all IceCube contribution

The role of auxin transport in the control of shoot branching

Branching is a highly plastic trait, enabling plants to adapt their growth form in response to environmental stimuli. In flowering plants, shoot branching is regulated through the activity of axillary buds, which grow into branches. Several classes of plant hormones have been shown to play pivotal roles in regulating bud outgrowth. Auxin derived from the primary shoot apex and active branches inhibits bud outgrowth, whereas cytokinin promotes it. Strigolactones also inhibit bud outgrowth, by changing properties of the auxin transport network, increasing the competition between buds. This occurs by modulating access to the polar auxin transport stream (PATS) in the main stem. The PATS provides directional, long distance transport of auxin down the stem, involving basal localisation of the auxin transporter PIN-FORMED1 (PIN1). Buds need to export their auxin across the stem towards the PATS in order to activate, but since PIN1 is mainly expressed in narrow files of cells associated with the stem vasculature, PIN1 itself it is unlikely to facilitate this connectivity. This thesis re-examines the role of auxin transport in the stem, showing that, besides the PIN1-mediated PATS, other auxin transport proteins constitute a more widespread and less polar auxin transport stream, allowing auxin exchange between the PATS and surrounding tissues. Disruption of this transport stream is shown to reduce bud-bud communication and to partially rescue the increased branching observed in strigolactone mutants. Furthermore, it is shown that distinct classes of auxin transport proteins within this stream can differentially affect bud outgrowth mediated by BRANCHED1 (BRC1). BRC1 is a transcription factor proposed to determine bud activation potential. Taken together, the data presented here provide a more comprehensive understanding of the shoot auxin transport network and its role in shoot branching regulation

Connective auxin transport contributes to strigolactone-mediated shoot branching control independent of the transcription factor BRC1

The shoot systems of plants are built by the action of the primary shoot apical meristem, established during embryogenesis. In the axil of each leaf produced by the primary meristem, secondary axillary shoot apical meristems are established. The dynamic regulation of the activity of these axillary meristems gives shoot systems their extraordinary plasticity of form. The ability of plants to activate or repress these axillary meristems appropriately requires communication between meristems that is environmentally sensitive. The transport network of the plant hormone auxin has long been implicated as a central player in this tuneable communication system, with other systemically mobile hormones, such as strigolactone and cytokinin, acting in part by modulating auxin transport. Until recently, the polar auxin transport stream, which provides a high conductance auxin transport route down stems dominated by the auxin export protein PIN-FORMED1 (PIN1), has been the focus for understanding long range auxin transport in the shoot. However, recently additional auxin exporters with important roles in the shoot have been identified, including PIN3, PIN4 and PIN7. These proteins contribute to a wider less polar stem auxin transport regime, which we have termed connective auxin transport (CAT), because of its role in communication across the shoot system. Here we present a genetic analysis of the role of CAT in shoot branching. We demonstrate that in Arabidopsis, CAT plays an important role in strigolactone-mediated shoot branching control, with the triple pin3pin4pin7 mutant able to suppress partially the highly branched phenotype of strigolactone deficient mutants. In contrast, the branchy phenotype of mutants lacking the axillary meristem-expressed transcription factor, BRANCHED1 (BRC1) is unaffected by pin3pin4pin7. We further demonstrate that mutation in the ABCB19 auxin export protein, which like PIN3 PIN4 and PIN7 is widely expressed in stems, has very different effects, implicating ABCB19 in auxin loading at axillary bud apices.Gatsby Charitable Foundatio

Validation of the Athletic Identity Measurement Scale in Youth Academy Soccer Players

The Athletic Identity Measurement Scale (AIMS) is a popular measure of Athletic Identity (AI). The purpose of the present study was to investigate the factor structure (7-item single factor and 3 factor model; Social Identity, Exclusivity and Negative Affectivity) of the AIMS within youth academy soccer players. A total of 259 male youth academy soccer players aged 12-18 years completed the AIMS. A series of confirmatory factor analyses, independent cluster modelling indicated support for the 7-item single-factor (AI) and the three-factor models but not within the same analysis. The results support the use of AIMS for the measurement of AI in elite male youth soccer players. Practitioners seeking to explore AI in youth soccer populations should use the three-factor model to glean further insight from the three subscales to support the design of more specific interventions where appropriate

In-Flight Reconfiguration with System-On-Module Based Architectures for Science Instruments on Nanosatellites

For science payloads on nanosatellite missions, there is a great interest in cost-effective, reliable and state-of-the-art computing performance. Highly integrated system architectures combine reconfigurable System-on-Chip (SoC) devices, memory and peripheral interfaces in a single System-on-Module (SoM) and offer low resource requirements regarding power and mass, but moderate to high processing power capabilities. The major advantages of these architectures are flexibility, (re)programmability, modularity and module reuse. However, it is a challenge to use SoM with COTS based memories devices in a radiation sensitive environment. In order to achieve these requirements, mitigation measures, such as the use of redundant or alternative memory devices and in-flight reconfiguration, are important in terms of reliability. Reprogramming strategies e.g. partial dynamic reconfiguration and scrubbing techniques are published in the past. With a remote sensing instrument for atmospheric temperature measurements using a SRAM-based Xilinx Zynq-7000 SoM, we combine some of these techniques with supervisor circuits to select the boot image from alternative memory devices. The approach distinguishes between programmable logic and processing system reconfiguration, and enables in-flight firmware updates in the case of Single Event Effect (SEE) hazards or changing measurement conditions

Network trade-offs and homeostasis in Arabidopsis shoot architectures.

Understanding the optimization objectives that shape shoot architectures remains a critical problem in plant biology. Here, we performed 3D scanning of 152 Arabidopsis shoot architectures, including wildtype and 10 mutant strains, and we uncovered a design principle that describes how architectures make trade-offs between competing objectives. First, we used graph-theoretic analysis to show that Arabidopsis shoot architectures strike a Pareto optimal that can be captured as maximizing performance in transporting nutrients and minimizing costs in building the architecture. Second, we identify small sets of genes that can be mutated to shift the weight prioritizing one objective over the other. Third, we show that this prioritization weight feature is significantly less variable across replicates of the same genotype compared to other common plant traits (e.g., number of rosette leaves, total volume occupied). This suggests that this feature is a robust descriptor of a genotype, and that local variability in structure may be compensated for globally in a homeostatic manner. Overall, our work provides a framework to understand optimization trade-offs made by shoot architectures and provides evidence that these trade-offs can be modified genetically, which may aid plant breeding and selection efforts.Gatsby Charitable Foundation Grant number GAT3272

How needs and preferences of employees influence participation in health promotion programs: A six-month follow-up study

Background: Low participation in health promotion programs (HPPs) might hamper their effectiveness. A potential reason for low participation is disagreement between needs and preferences of potential participants and the actual HPPs offered. This study aimed to investigate employees' need and preferences for HPPs, whether these are matched by what their employers provide, and whether a higher agreement enhanced participation. Methods: Employees of two organizations participated in a six-month follow-up study (n = 738). At baseline, information was collected on employees' needs and preferences for the topic of the HPP (i.e. physical activity, healthy nutrition, smoking cessation, stress management, general health), whether they favored a HPP via their employer or at their own discretion, and their preferred HPP regarding three components with each two alternatives: mode of delivery (individual vs. group), intensity (single vs. multiple meetings), and content (assignments vs. information). Participation in HPPs was assessed at six-month

A comprehensive microarray-based DNA methylation study of 367 hematological neoplasms

Background: Alterations in the DNA methylation pattern are a hallmark of leukemias and lymphomas. However, most epigenetic studies in hematologic neoplasms (HNs) have focused either on the analysis of few candidate genes or many genes and few HN entities, and comprehensive studies are required. Methodology/Principal Findings: Here, we report for the first time a microarray-based DNA methylation study of 767 genes in 367 HNs diagnosed with 16 of the most representative B-cell (n = 203), T-cell (n = 30), and myeloid (n = 134) neoplasias, as well as 37 samples from different cell types of the hematopoietic system. Using appropriate controls of B-, T-, or myeloid cellular origin, we identified a total of 220 genes hypermethylated in at least one HN entity. In general, promoter hypermethylation was more frequent in lymphoid malignancies than in myeloid malignancies, being germinal center mature B-cell lymphomas as well as B and T precursor lymphoid neoplasias those entities with highest frequency of gene-associated DNA hypermethylation. We also observed a significant correlation between the number of hypermethylated and hypomethylated genes in several mature B-cell neoplasias, but not in precursor B- and T-cell leukemias. Most of the genes becoming hypermethylated contained promoters with high CpG content, and a significant fraction of them are targets of the polycomb repressor complex. Interestingly, T-cell prolymphocytic leukemias show low levels of DNA hypermethylation and a comparatively large number of hypomethylated genes, many of them showing an increased gene expression. Conclusions/Significance: We have characterized the DNA methylation profile of a wide range of different HNs entities. As well as identifying genes showing aberrant DNA methylation in certain HN subtypes, we also detected six genes—DBC1, DIO3, FZD9, HS3ST2, MOS, and MYOD1—that were significantly hypermethylated in B-cell, T-cell, and myeloid malignancies. These might therefore play an important role in the development of different HNs